Description

2-Iodo-3,4-Difluoroanisole is a high-value, multi-functional halogenated anisole derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring iodine and fluorine substituents on the aromatic ring, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the iodine and fluorine atoms contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine moiety acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex biaryl systems.
• Chemical Biology & Diagnostics: Utilized as a radiolabeling precursor or a probe for studying biological mechanisms and developing diagnostic agents.

Basic Information

Product Name	2-Iodo-3,4-Difluoroanisole
CAS No.	936498-08-7
Molecular Formula	C7H5F2IO
Molecular Weight	269.02 g/mol
Synonyms	1-Iodo-2,3-Difluoro-4-Methoxybenzene; 2,3-Difluoro-1-Iodo-4-Methoxybenzene; 3,4-Difluoro-2-Iodoanisole; Benzene, 1-iodo-2,3-difluoro-4-methoxy-; 2-Iodo-3,4-difluoromethoxybenzene; 4-Methoxy-2,3-difluoroiodobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Iodo-3,4-Difluoroanisole is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, and NMR analysis, to ensure compliance with industry standards and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.