Description

2-(2,2,2-Trifluoro-Ethoxy)-3,5-Difluoro-Benzeneboronic Acid is a high-value, multi-fluorinated boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require advanced intermediates for developing new active ingredients. The presence of both the trifluoroethoxy and difluoro substituents imparts unique electronic and steric properties, making it a sought-after reagent for creating novel compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of novel organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic systems are crucial.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Probe Design: Utilized in the creation of molecular probes and bio-conjugates for studying biological processes and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	2-(2,2,2-Trifluoro-Ethoxy)-3,5-Difluoro-Benzeneboronic Acid
CAS No.	936250-26-9
Molecular Formula	C8H6BF5O3
Molecular Weight	255.94 g/mol
Synonyms	[3,5-Difluoro-2-(2,2,2-trifluoroethoxy)phenyl]boronic acid; 2-(2,2,2-Trifluoroethoxy)-3,5-difluorophenylboronic acid; (3,5-Difluoro-2-(trifluoroethoxy)phenyl)boronic acid; Boronic acid, B-[3,5-difluoro-2-[(2,2,2-trifluoroethoxy)phenyl]-; 936250-26-9; 3,5-Difluoro-2-(trifluoroethoxy)benzeneboronic Acid
EINECS	Contact for details

Quality Control

Our production of 2-(2,2,2-Trifluoro-Ethoxy)-3,5-Difluoro-Benzeneboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot undergoes comprehensive analytical characterization, including HPLC purity assay, NMR spectroscopy for structural confirmation, and residual solvent analysis. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality management system is designed to support regulatory filings, and we can supply material suitable for use under cGMP guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain purity. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.