Description

2-(2,2-Difluoro-Ethoxy)-3,5-Difluoro-Benzeneboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a key intermediate in cross-coupling reactions, enabling the efficient construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex drug candidates, especially in fluorinated compound research.
• Agrochemical Synthesis: Used in the development of advanced, fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity and stability.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, liquid crystals, and polymers with specific optical or electronic properties.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological processes and target identification.
• Catalyst Ligand Development: Acts as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-purity boronic acid reagents.

Basic Information

Product Name	2-(2,2-Difluoro-Ethoxy)-3,5-Difluoro-Benzeneboronic Acid
CAS No.	936250-25-8
Molecular Formula	C8H7BF4O3
Molecular Weight	238.0 g/mol
Synonyms	[2-(2,2-Difluoroethoxy)-3,5-difluorophenyl]boronic acid; 3,5-Difluoro-2-(2,2-difluoroethoxy)benzeneboronic acid; 2-(2,2-Difluoroethoxy)-3,5-difluorobenzeneboronic acid; Boronic acid, B-[2-(2,2-difluoroethoxy)-3,5-difluorophenyl]-; 936250-25-8; CAS 936250-25-8
EINECS	Contact for details

Quality Control

Our 2-(2,2-Difluoro-Ethoxy)-3,5-Difluoro-Benzeneboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality systems support compliance with global regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%
Solubility	Soluble in common organic solvents (e.g., DMF, THF, DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.