Description

3-(2,2,2-Trifluoro-Ethoxy)-4,5-Difluoro-Benzeneboronic Acid is a high-value, multi-fluorinated benzeneboronic acid derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise construction of complex molecules, particularly in the development of pharmaceuticals and agrochemicals where the introduction of fluorine atoms is essential for modulating biological activity, metabolic stability, and lipophilicity. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoroethoxy and difluoro groups enhance product efficacy and environmental profile.
• Material Science Research: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers for electronic and optical applications.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the creation of fluorinated molecular probes for imaging and diagnostic applications.
• Process Chemistry & Scale-up: Provides a reliable and consistent building block for optimizing synthetic routes from laboratory to pilot plant and commercial production scales.

Basic Information

Product Name	3-(2,2,2-Trifluoro-Ethoxy)-4,5-Difluoro-Benzeneboronic Acid
CAS No.	936250-24-7
Molecular Formula	C8H6BF5O3
Molecular Weight	255.94 g/mol
Synonyms	[4,5-Difluoro-3-(2,2,2-trifluoroethoxy)phenyl]boronic acid; 3-(2,2,2-Trifluoroethoxy)-4,5-difluorophenylboronic acid; 4,5-Difluoro-3-(trifluoroethoxy)benzeneboronic acid; 936250-24-7; Boronic acid, B-[4,5-difluoro-3-(2,2,2-trifluoroethoxy)phenyl]-; 3-Trifluoroethoxy-4,5-difluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoro-Ethoxy)-4,5-Difluoro-Benzeneboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your compliance needs for research, development, and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.