Description

(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Hydroxyimino)Acetamido)-8-Oxo-3-Vinyl-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide is a key advanced pharmaceutical intermediate, specifically a cephalosporin derivative, essential for the synthesis of modern β-lactam antibiotics. Its value lies in its role as a critical building block for developing potent, broad-spectrum antibacterial agents, addressing the global need for effective treatments against resistant pathogens. This high-purity compound is primarily required by pharmaceutical R&D laboratories, active pharmaceutical ingredient (API) manufacturers, and fine chemical synthesis facilities focused on next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced-generation cephalosporin antibiotics.
• API Manufacturing: Used in the production of active pharmaceutical ingredients for injectable antibacterial drugs.
• Antibiotic Research & Development: Serves as a key scaffold for medicinal chemists developing new β-lactam compounds with improved efficacy and resistance profiles.
• Fine Chemical Synthesis: Employed in complex multi-step organic syntheses requiring high stereochemical purity.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical production.
• Process Chemistry Development: Integral for scaling up and optimizing manufacturing routes for cephalosporin-based therapeutics.

Basic Information

Product Name	(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Hydroxyimino)Acetamido)-8-Oxo-3-Vinyl-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide
CAS No.	934986-48-8
Molecular Formula	C14H13N5O6S2
Molecular Weight	411.41 g/mol
Synonyms	(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide; Ceftaroline Fosamil Intermediate; Ceftaroline Fosamil Impurity; (6R,7R)-3-Vinyl-7-[2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-oxide; TAK-599 Intermediate; PPI-0903 Intermediate; Zinforo Intermediate; Teflaro Intermediate
EINECS	Contact for details

Quality Control

Our (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-Yl)-2-(Hydroxyimino)Acetamido)-8-Oxo-3-Vinyl-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 5-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccated environment after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.