Description

Urelumab CAS NO 934823-49-1 is a potent immunomodulatory monoclonal antibody that functions as an agonist for the CD137 (4-1BB) receptor. This compound is of significant interest for its ability to enhance T-cell activation and proliferation, offering a powerful mechanism for therapeutic intervention. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development of novel immunotherapies for oncology and autoimmune diseases.

Application

• Immuno-oncology Research: Investigated as a key component in combination therapies to boost anti-tumor immune responses in preclinical and clinical studies.
• Therapeutic Antibody Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the formulation of biologic drugs targeting the 4-1BB pathway.
• Cell-based Assays: Used in vitro to study T-cell co-stimulation, cytokine release, and the mechanisms of immune checkpoint modulation.
• Biopharmaceutical Manufacturing: Employed in process development and scale-up for the production of monoclonal antibody therapeutics.
• Drug Discovery Screening: Acts as a positive control in high-throughput screening assays designed to identify novel immunomodulators.

Basic Information

Product Name	Urelumab
CAS No.	934823-49-1
Molecular Formula	C6440H9916N1704O2016S48
Molecular Weight	~145 kDa
Synonyms	BMS-663513; Anti-4-1BB Agonistic Monoclonal Antibody; Anti-CD137 Agonist; Anti-TNFRSF9 Antibody; 4-1BB Ligand; Urelumab (INN); Immunoglobulin G4, anti-(human 4-1BB antigen) (human-mouse monoclonal BMS-663513 γ4-chain), disulfide with human-mouse monoclonal BMS-663513 κ-chain, dimer
EINECS	Contact for details

Quality Control

Our Urelumab is manufactured under strict quality management systems. Each batch is subjected to a comprehensive suite of analytical tests, including purity assessment by HPLC, identity confirmation, and rigorous testing for bioburden and endotoxins. Certificates of Analysis (COA) detailing full specifications are provided to ensure compliance with GMP guidelines for biopharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant when opened.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (HPLC/MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0% (Monomer)
Protein Content (UV)	90% - 110% of label claim
Endotoxin	< 1.0 EU/mg
Bioburden	Meets Ph. Eur. 2.6.12 requirements
Potency (Cell-based Assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.