Description

2-Chlorotritylchloride Resin CAS NO 934816-82-7 is a highly versatile and functionalized polymeric support widely used in solid-phase synthesis. Its core value lies in its exceptional ability to anchor carboxylic acids and other nucleophiles via a highly acid-labile linkage, enabling efficient and high-yielding peptide and small molecule assembly. This resin is an indispensable tool for researchers and manufacturers in pharmaceutical development, combinatorial chemistry, and the production of complex organic compounds, where reliable and cleavable protecting groups are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary application for the efficient, stepwise assembly of peptides, including difficult sequences, due to its mild cleavage conditions.
• Combinatorial Library Generation: Enables the parallel synthesis of diverse compound libraries for high-throughput screening in drug discovery.
• Small Molecule Organic Synthesis: Used as a polymeric support for the synthesis of complex natural products, heterocycles, and other bioactive molecules.
• Linker for Sensitive Molecules: Ideal for anchoring acid-sensitive substrates, as cleavage is achieved under very mild acidic conditions (e.g., 1-5% TFA in DCM).
• Preparation of C-terminal Peptide Amides and Acids: Facilitates the synthesis of peptides with free C-terminal carboxylic acids or amides upon cleavage.
• Oligonucleotide and Glycopeptide Synthesis: Supports specialized synthesis where a stable yet readily cleavable anchor is required.

Basic Information

Product Name	2-Chlorotritylchloride Resin
CAS No.	934816-82-7
Molecular Formula	Typically represented as (C21H14Cl2)n (for the functional group on polystyrene support)
Molecular Weight	Variable (depends on loading capacity and polymer backbone). Contact for details.
Synonyms	2-Chlorotrityl Chloride Polystyrene Resin; CTC Resin; 2-Chlorotrityl Chloride Resin; Chloro(2-chlorophenyl)diphenylmethane Polystyrene; 2-Chlorotritylchloride-Loaded Resin; (2-Chlorophenyl)diphenylmethyl Chloride Resin; Wang CTC Resin; Acid-Labile Chlorotrityl Resin
EINECS	Contact for details

Quality Control

Our 2-Chlorotritylchloride Resin is manufactured under strict quality protocols to ensure batch-to-batch consistency and performance in sensitive synthetic applications. Each lot is characterized for critical parameters including loading capacity, particle size distribution, and solvent compatibility. Comprehensive Certificates of Analysis (COA) detailing purity, functional group analysis, and physical specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive). Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere such as nitrogen or argon to maintain optimal reactivity and shelf life. Keep the container sealed when not in use.

Specification

Item	Specification
Appearance	Off-white to pale yellow beads
Loading Capacity	0.8 - 1.8 mmol/g (typical)
Particle Size	100-200 mesh (75-150 μm)
Identification (IR)	Conforms to structure
Chlorine Content	By elemental analysis
Solvent Content	< 2% (by loss on drying)
Swelling Volume	Reported (DCM, DMF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.