Description

(S)-4-Fluoro-5-(2-Methyl-[1,4]Diazepane-1-Sulfonyl)Isoquinoline 2Hcl is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of targeted therapeutic agents with enhanced efficacy and selectivity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel drug candidates, particularly within oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Protease Inhibitor Development: Potential application in the synthesis of compounds targeting specific enzymes due to the diazepane-sulfonyl moiety.
• Kinase Inhibitor Synthesis: Employed as a building block for creating selective kinase inhibitors, relevant in oncology research.
• Chemical Biology Probes: Utilized in the design of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring high-fidelity chiral intermediates.

Basic Information

Product Name	(S)-4-Fluoro-5-(2-Methyl-[1,4]Diazepane-1-Sulfonyl)Isoquinoline 2Hcl
CAS No.	934400-38-1
Molecular Formula	C₁₅H₂₀F N₃ O₂ S • 2HCl
Molecular Weight	422.33 g/mol (Free base: 349.40 g/mol)
Synonyms	(S)-4-Fluoro-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline dihydrochloride; (S)-5-[(2-Methyl-1,4-diazepan-1-yl)sulfonyl]-4-fluoroisoquinoline dihydrochloride; 4-Fluoro-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline (S)-isomer 2HCl; 934400-38-1; (S)-4-Fluoro-5-(2-methyl-1,4-diazepane-1-sulfonyl)isoquinoline hydrochloride (1:2)
EINECS	Contact for details

Quality Control

Our (S)-4-Fluoro-5-(2-Methyl-[1,4]Diazepane-1-Sulfonyl)Isoquinoline 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research-grade and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and pre-clinical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.