Description

Lansoprazole-D4 CAS NO 934294-22-1 is a deuterated analog of the proton pump inhibitor Lansoprazole, where four hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is critical for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based assays. It is an essential tool for pharmaceutical research and development, clinical laboratories, and regulatory agencies involved in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity internal standard for the precise quantification of Lansoprazole in biological matrices (plasma, serum, urine) during bioanalytical method development and validation.
• Drug Metabolism Studies (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) research to track and quantify the parent drug and its metabolites.
• Clinical Pharmacology: Supports therapeutic drug monitoring (TDM) and pharmacokinetic/pharmacodynamic (PK/PD) modeling studies in clinical trials.
• Pharmaceutical Quality Control: Can be utilized in advanced analytical methods for impurity profiling and stability testing of Lansoprazole drug substances and products.
• Forensic and Anti-Doping Analysis: Enables accurate detection and quantification in specialized testing protocols where high specificity is required.

Basic Information

Product Name	Lansoprazole-D4
CAS No.	934294-22-1
Molecular Formula	C16H10D4F3N3O2S
Molecular Weight	373.40 g/mol
Synonyms	Lansoprazole-d4; Deuterated Lansoprazole; 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-d4; AG-1749-d4; (RS)-Lansoprazole-d4; Prevacid-d4; Lanzor-d4; Ogast-d4
EINECS	Contact for details

Quality Control

Our Lansoprazole-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for structural confirmation and isotopic enrichment verification, and HPLC for chemical and isotopic purity assessment. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic purity, and residual solvents, ensuring compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by HPLC)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.