Description

3-Chloro-4-Trifluoromethyl-Biphenyl is a high-purity, multi-functional biphenyl derivative, serving as a critical advanced intermediate in modern chemical synthesis. Its value lies in the unique combination of chlorine and trifluoromethyl substituents, which impart desirable electronic and steric properties for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a core component in the development of high-performance liquid crystals for display technologies, leveraging its rigid biphenyl structure.
• Organic Light-Emitting Diodes (OLEDs): Acts as a precursor for electron-transport materials or host materials in OLED devices due to its favorable electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create more complex biaryl systems.
• Material Science Research: Employed in academic and industrial R&D for creating novel polymers and organic semiconductors with tailored properties.

Basic Information

Product Name	3-Chloro-4-Trifluoromethyl-Biphenyl
CAS No.	933674-79-4
Molecular Formula	C13H8ClF3
Molecular Weight	256.65 g/mol
Synonyms	3-Chloro-4'-(trifluoromethyl)biphenyl; 1-Chloro-2-(4-(trifluoromethyl)phenyl)benzene; 4-(3-Chlorophenyl)benzotrifluoride; [1,1'-Biphenyl]-3-chloro-4'-trifluoromethyl; 3-Chloro-4-trifluoromethyl-1,1'-biphenyl; 3-Chloro-4'-trifluoromethylbiphenyl; 3-Chloro-4-(trifluoromethyl)biphenyl
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-4-Trifluoromethyl-Biphenyl is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with detailed control of key impurities. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.