Description

4-Fluorobenzylthioacetonitrile is a versatile fluorinated organic intermediate featuring a reactive nitrile group and a benzylthioether linkage. This compound matters for its role as a critical building block in the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors seeking to introduce fluorinated motifs and sulfur-containing functional groups into target structures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the fluorine atom and nitrile group can improve biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers and functionalized polymers for advanced materials with specific electronic or surface properties.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological processes, leveraging the reactivity of the nitrile and thioether groups.

Basic Information

Product Name	4-Fluorobenzylthioacetonitrile
CAS No.	933673-53-1
Molecular Formula	C9H8FNS
Molecular Weight	181.23 g/mol
Synonyms	2-[(4-Fluorophenyl)methylsulfanyl]acetonitrile; (4-Fluorobenzylthio)acetonitrile; Acetonitrile, [(4-fluorophenyl)methyl]thio-; p-Fluorobenzylthioacetonitrile; 4-Fluorobenzyl mercaptoacetonitrile; 4-Fluorobenzyl thioglycolonitrile; [(4-Fluorophenyl)methylsulfanyl]ethanenitrile
EINECS	Contact for details

Quality Control

Our 4-Fluorobenzylthioacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.