Description

(2S)-tert-Butyl 3-Cyano-2-Methyl-4-Oxopiperidine-1-Carboxylate is a high-purity chiral piperidine derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of complex, biologically active molecules with precise stereochemical control. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug discovery.
• Chiral Synthesis: Utilized in asymmetric synthesis to introduce the (2S) stereocenter into complex molecular architectures.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides with specific activity profiles.
• Chemical Biology Probes: Used to create labeled compounds and probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes under cGMP conditions.
• Academic & Industrial R&D: Employed in medicinal chemistry laboratories for lead optimization and structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	(2S)-tert-Butyl 3-Cyano-2-Methyl-4-Oxopiperidine-1-Carboxylate
CAS No.	2212021-56-0
Molecular Formula	C12H18N2O3
Molecular Weight	238.28 g/mol
Synonyms	(2S)-1-Boc-3-cyano-2-methyl-4-oxopiperidine; (2S)-1-(tert-Butoxycarbonyl)-3-cyano-2-methylpiperidin-4-one; tert-Butyl (2S)-3-cyano-2-methyl-4-oxo-1-piperidinecarboxylate; 1-Boc-3-cyano-2-methyl-4-piperidone (S-enantiomer); (S)-tert-Butyl 3-cyano-2-methyl-4-oxopiperidine-1-carboxylate; (S)-1-Boc-3-cyano-2-methyl-4-piperidone; (2S)-3-Cyano-2-methyl-4-oxo-1-piperidinecarboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (2S)-tert-Butyl 3-Cyano-2-Methyl-4-Oxopiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.