Description

Cyanogen Bromide is a highly reactive and versatile reagent, primarily recognized for its role as a cyanylating and cleaving agent in organic synthesis and biochemistry. Its significance lies in its ability to modify peptides and proteins, making it an indispensable tool for structural analysis and bioconjugation. This compound is essential for research laboratories, pharmaceutical developers, and chemical manufacturers focused on peptide synthesis, protein sequencing, and the production of specialized intermediates.

Application

• Peptide and Protein Chemistry: Key reagent for C-terminal sequencing via the cyanogen bromide cleavage method at methionine residues.
• Bioconjugation: Used to activate carboxyl groups or modify specific amino acid side chains for coupling biomolecules.
• Organic Synthesis: Serves as a cyanylating agent to introduce the nitrile (CN) group into organic molecules for building complex heterocycles and pharmaceuticals.
• Pharmaceutical Intermediates: Employed in the synthesis of active pharmaceutical ingredients (APIs) and other fine chemicals.
• Research & Development: A critical tool in academic and industrial R&D for studying protein structure-function relationships.
• Cross-linking Agent: Can be used for the cross-linking of polymers or biomaterials under controlled conditions.

Basic Information

Product Name	Cyanogen Bromide
CAS No.	506-68-3
Molecular Formula	BrCN
Molecular Weight	105.92 g/mol
Synonyms	Bromine Cyanide; Bromocyan; Bromocyanide; Bromocyanogen; Cyanobromide; Cyanogen Monobromide; Bromoformonitrile
EINECS	208-051-2

Quality Control

Our Cyanogen Bromide is manufactured under stringent quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic and research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific customer requirements for research or GMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystals or crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Melting Point	49 - 52 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.