Description

2,2-Difluoro-4-Methylsulfanyl-Benzo[1,3]Dioxole CAS NO 933673-39-3 is a high-purity, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a benzo[1,3]dioxole core with fluorine and methylsulfanyl substituents, making it a valuable precursor for creating complex molecules with tailored properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and advanced organic electronic materials due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the sulfur and oxygen donor atoms.
• Fluorine Chemistry Building Block: Essential for introducing the difluoromethylene ether moiety into complex molecules, a group known to improve metabolic stability and membrane permeability.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this specialized scaffold.

Basic Information

Product Name	2,2-Difluoro-4-Methylsulfanyl-Benzo[1,3]Dioxole
CAS No.	933673-39-3
Molecular Formula	C8H6F2O2S
Molecular Weight	204.20 g/mol
Synonyms	4-(Methylthio)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-4-(methylthio)-1,3-benzodioxole; 2,2-Difluoro-4-methylsulfanyl-1,3-benzodioxole; Benzo[1,3]dioxole, 2,2-difluoro-4-(methylthio)-; 933673-39-3; 4-Methylsulfanyl-2,2-difluoro-benzo[1,3]dioxole
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-4-Methylsulfanyl-Benzo[1,3]Dioxole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for prolonged storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.