Description

5-Iodo-2-Methoxybenzonitrile is a versatile halogenated aromatic nitrile building block with significant utility in advanced organic synthesis. Its molecular structure, featuring iodine, methoxy, and nitrile functional groups, makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the iodine moiety allows for further functionalization.
• Material Science: Serves as a building block for organic electronic materials, including liquid crystals and charge-transport molecules.
• Cross-Coupling Reactions: The aryl iodide group is highly reactive in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) for carbon-carbon bond formation.
• Ligand Preparation: Used to synthesize functionalized ligands for transition metal catalysts in asymmetric synthesis.
• Chemical Research: A valuable reagent for academic and industrial research in methodology development and heterocyclic chemistry.

Basic Information

Product Name	5-Iodo-2-Methoxybenzonitrile
CAS No.	933672-32-3
Molecular Formula	C8H6INO
Molecular Weight	259.05 g/mol
Synonyms	2-Methoxy-5-iodobenzonitrile; 5-Iodo-2-methoxybenzonitrile; 2-Methoxy-5-iodobenzene carbonitrile; 5-Iodo-o-anisonitrile; Benzonitrile, 5-iodo-2-methoxy-; 933672-32-3
EINECS	Contact for details

Quality Control

Our 5-Iodo-2-Methoxybenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation by FT-IR and NMR, and residual solvent analysis. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.