Description

4-Chloro-3-Ethoxybenzonitrile is a versatile aromatic nitrile derivative characterized by its chloro and ethoxy substituents, serving as a crucial advanced intermediate in modern synthetic chemistry. Its value lies in providing a reactive nitrile group and a halogenated aromatic core, enabling the construction of complex molecules for high-value applications. This compound is primarily needed by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers due to its rigid, functionalized benzene ring.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Chloro-3-Ethoxybenzonitrile
CAS No.	933585-28-5
Molecular Formula	C9H8ClNO
Molecular Weight	181.62 g/mol
Synonyms	3-Ethoxy-4-chlorobenzonitrile; 4-Chloro-3-ethoxybenzenecarbonitrile; Benzonitrile, 4-chloro-3-ethoxy-; 4-Chloro-m-ethoxybenzonitrile; 1-Chloro-2-ethoxy-4-cyanobenzene; 2-Chloro-6-ethoxybenzonitrile; 4-Cyano-2-chlorophenetole; 933585-28-5
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Ethoxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.