Description

Bromoacetamide-Peg3-Propargyl is a heterobifunctional crosslinker and bioconjugation reagent featuring a reactive bromoacetamide group and a terminal alkyne (propargyl) group, connected by a triethylene glycol (PEG3) spacer. This molecular architecture is critical for site-specific protein labeling, antibody-drug conjugate (ADC) development, and the construction of complex biomolecular assemblies. It is an essential tool for researchers and manufacturers in pharmaceutical R&D, bioconjugation chemistry, and proteomics who require precise and stable linkages under mild aqueous conditions.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: Site-specific conjugation of cytotoxic payloads to antibodies via the bromoacetamide group, which selectively reacts with cysteine thiols.
• Protein and Peptide Labeling: Introduction of alkyne handles onto biomolecules for subsequent "click chemistry" reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Surface Functionalization: Modification of nanoparticles, biosensors, or microarray surfaces to create reactive platforms for biomolecule immobilization.
• Chemical Biology Probes: Construction of activity-based probes (ABPs) or affinity tags for target identification and validation in complex biological systems.
• Polymer and Material Science: Serving as a functional monomer or crosslinking agent for synthesizing smart polymers with tailored biological activity.
• Diagnostic Reagent Development: Creating stable conjugates for immunoassays, fluorescence in situ hybridization (FISH), and other diagnostic platforms.

Basic Information

Product Name	Bromoacetamide-Peg3-Propargyl
CAS No.	932741-11-2
Molecular Formula	C₁₄H₂₃BrN₂O₅
Molecular Weight	379.25 g/mol
Synonyms	N-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl)-2-bromoacetamide; Propargyl-PEG3-bromoacetamide; Bromoacetamide-PEG3-Alkyne; 2-Bromo-N-[2-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]ethyl]acetamide; Alkyne-PEG3-Bromoacetamide; Bromoacetyl-PEG3-Propargyl; Heterobifunctional PEG Linker, Bromoacetamide-Alkyne; Propargyl-PEG3-Bromoacetyl
EINECS	Contact for details

Quality Control

Our Bromoacetamide-Peg3-Propargyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support cGMP compliance for advanced applications and can tailor quality documentation to meet specific regulatory or project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.