Description

Amatuximab CAS NO 931402-35-6 is a high-purity monoclonal antibody designed for targeted therapeutic applications. This compound is critical for advanced research and development in oncology, offering a specific mechanism of action against mesothelin-expressing cells. It is primarily utilized by pharmaceutical companies, biotechnology research institutions, and clinical laboratories engaged in the development of novel cancer immunotherapies and diagnostic agents.

Application

• Primary therapeutic agent in clinical research for malignant pleural mesothelioma.
• Key component in combination therapy studies for pancreatic and ovarian cancers.
• Utilized in the development of antibody-drug conjugates (ADCs) targeting solid tumors.
• Essential reagent for in vitro and in vivo preclinical studies to evaluate anti-tumor efficacy.
• Used in diagnostic assay development for the detection of mesothelin expression in tissue samples.
• Critical for pharmacokinetic and pharmacodynamic modeling in drug development pipelines.
• Employed in the formulation of targeted delivery systems for improved therapeutic index.

Basic Information

Product Name	Amatuximab
CAS No.	931402-35-6
Molecular Formula	C6480H10006N1732O2020S44
Molecular Weight	~145.8 kDa
Synonyms	MORAb-009; Anti-Mesothelin Monoclonal Antibody; MORAb009; Monoclonal Antibody MORAb-009; Humanized Anti-Mesothelin IgG1 kappa; CAS 931402-35-6; Therapeutic Antibody MORAb-009
EINECS	Contact for details

Quality Control

Our Amatuximab is manufactured under strict quality systems to ensure high purity, potency, and consistency for research and development use. Each batch is subjected to a comprehensive suite of analytical tests including SDS-PAGE, size-exclusion HPLC (SE-HPLC), and binding affinity assays to confirm identity and biological activity. Certificates of Analysis (COA) detailing purity, endotoxin levels, and sterility are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C to -80°C. Reconstituted solutions should be aliquoted and stored at 2-8°C for short-term use or at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Purity (SDS-PAGE, reduced & non-reduced)	>95%
Purity (SE-HPLC, monomer)	>90%
Protein Concentration	As per COA (typically 1-10 mg/mL)
Endotoxin Level	<1.0 EU/mg
Sterility	Sterile (Membrane Filtration)
Binding Affinity (SPR/BLI)	As per COA
Biological Activity (Cell-based assay)	As per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.