Description

2-Hydroxy-6-Cyano-4-Oxa-Tricyclo[4.2.1.03,7]Decyl-5-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex, rigid tricyclic oxa-bridged structure. This compound matters as a critical building block for the synthesis of novel, high-value active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, where it serves as a key precursor for drug discovery and development programs targeting complex diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex, biologically active molecules and novel APIs.
• Drug Discovery & Development: Used in medicinal chemistry for lead optimization and the construction of proprietary compound libraries.
• Asymmetric Synthesis: Serves as a valuable scaffold in catalytic asymmetric reactions due to its rigid, three-dimensional structure.
• Chemical Biology Research: Employed in the development of molecular probes and tools for studying biological pathways.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for candidate drugs.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis.

Basic Information

Product Name	2-Hydroxy-6-Cyano-4-Oxa-Tricyclo[4.2.1.03,7]Decyl-5-One
CAS No.	931398-54-8
Molecular Formula	C10H9NO3
Molecular Weight	191.18 g/mol
Synonyms	2-Hydroxy-6-cyano-4-oxatricyclo[4.2.1.03,7]nonan-5-one; 4-Oxa-tricyclo[4.2.1.03,7]nonane-2-hydroxy-6-carbonitrile-5-one; (1R,2S,5R,6S)-2-Hydroxy-6-cyano-4-oxatricyclo[4.2.1.03,7]nonan-5-one (stereoisomer); (1S,2R,5S,6R)-2-Hydroxy-6-cyano-4-oxatricyclo[4.2.1.03,7]nonan-5-one (stereoisomer); Tricyclic Oxa-Bridged Nitrile Ketone; Advanced Pharmaceutical Intermediate 931398-54-8
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-6-Cyano-4-Oxa-Tricyclo[4.2.1.03,7]Decyl-5-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (for specified isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.