Description

(-)-N, n-Bisdesmethyl Tramadol is a key intermediate in the synthesis of novel pharmaceutical compounds and a metabolite of the analgesic tramadol. This compound is of significant interest for research and development in medicinal chemistry, particularly in the study of opioid receptor activity and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and academic institutions focused on neuropharmacology and drug metabolism studies.

Application

• Pharmaceutical Intermediate: Critical building block in the research and synthesis of new analgesic and central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical testing.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research to understand the metabolism and biological activity of tramadol and related compounds.
• Biochemical Research: Employed in studies investigating the binding affinity and functional activity at opioid receptors (e.g., μ-opioid receptor).
• Impurity Profiling: Serves as a known impurity standard for the characterization and control of tramadol API and finished drug products according to ICH guidelines.

Basic Information

Product Name	(-)-N, n-Bisdesmethyl Tramadol
CAS No.	931115-27-4
Molecular Formula	C14H21NO2
Molecular Weight	235.33 g/mol
Synonyms	(1R,2R)-2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol; O-Desmethyltramadol Metabolite; (-)-O-Desmethyltramadol; (1R,2R)-Tramadol Metabolite M1; (-)-M1 Metabolite; Tramadol Metabolite O-Desmethyltramadol
EINECS	Contact for details

Quality Control

Our (-)-N, n-Bisdesmethyl Tramadol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identity confirmation by spectroscopic methods (IR, NMR, MS). We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.