Description

n-Hex-5-Ynyl-2-Iodo-Acetamide is a specialized organic building block featuring a terminal alkyne and an iodoacetamide functional group. This unique bifunctional structure makes it a valuable reagent for click chemistry, bioconjugation, and the synthesis of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel compounds and probes.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for targeted drug delivery systems.
• Bioconjugation & Probe Synthesis: The iodoacetamide group selectively reacts with thiols (cysteine residues), while the alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC), allowing for dual-labeling strategies in proteins, peptides, and antibodies.
• Polymer & Materials Science: Used as a functional monomer or cross-linker to introduce alkyne handles into polymers for post-polymerization modification, creating smart materials and surfaces.
• Chemical Biology Research: Enables the synthesis of activity-based probes (ABPs) and affinity tags for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Employed in the synthesis of novel herbicide and pesticide candidates with potential for improved efficacy and selectivity.
• Ligand & Catalyst Development: Acts as a precursor for creating specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).

Basic Information

Product Name	n-Hex-5-Ynyl-2-Iodo-Acetamide
CAS No.	930800-38-7
Molecular Formula	C8H12INO
Molecular Weight	265.09 g/mol
Synonyms	2-Iodo-N-(hex-5-yn-1-yl)acetamide; N-(5-Hexynyl)-2-iodoacetamide; 5-Hexyn-1-amine, N-(iodoacetyl)-; Iodoacetamide-C6-alkyne; Alkyne-PEG1-Iodoacetamide; Terminal Alkyne Iodoacetamide Reagent; Hex-5-ynyl iodoacetamide; 6-Iodoacetamido-1-hexyne
EINECS	Contact for details

Quality Control

Our n-Hex-5-Ynyl-2-Iodo-Acetamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by NMR (¹H and ¹³C), HPLC, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) under an inert atmosphere for long-term stability. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.