Description

Adamts-5 CAS NO 929634-33-3 is a high-purity, biologically active compound primarily used as a potent and selective inhibitor of the ADAMTS-5 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5) enzyme. This specificity makes it an invaluable research tool for studying extracellular matrix degradation and related pathological processes. It is essential for pharmaceutical R&D teams, academic researchers, and biotech companies focused on osteoarthritis, cancer metastasis, and other connective tissue disorders.

Application

• Biomedical Research: Used as a selective inhibitor to study the role of ADAMTS-5 in articular cartilage degradation and the pathogenesis of osteoarthritis.
• Drug Discovery & Development: Serves as a key pharmacological tool and reference standard in screening assays for developing novel therapeutic agents targeting aggrecanases.
• Cell Biology Studies: Employed in in vitro cell culture models to investigate mechanisms of extracellular matrix remodeling, cell migration, and inflammation.
• Enzyme Kinetics & Biochemical Assays: Utilized to determine inhibitory constants (Ki, IC50) and elucidate the structure-activity relationship (SAR) of ADAMTS-5 inhibitors.
• Academic Research: Fundamental research in universities and institutes exploring connective tissue biology, arthritis, and related disease models.

Basic Information

Product Name	Adamts-5
CAS No.	929634-33-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ADAMTS-5 Inhibitor; Aggrecanase-2 Inhibitor; (4S,5R)-N-{(1S)-2-Amino-1-[(3,5-difluorophenyl)methyl]ethyl}-4,5-dihydro-5-methyl-4-({[4-(2-methyl-2-propanyl)phenyl]sulfonyl}amino)-3H-pyrrole-3-carboxamide; TIS-5; TIS5; CAS 929634-33-3
EINECS	Contact for details

Quality Control

Our Adamts-5 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical methods is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Potency (Enzymatic Assay)	≥90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.