Description

Rimonabant-D10 is a deuterium-labeled analog of Rimonabant, a selective cannabinoid receptor type 1 (CB1) antagonist. This stable isotope-labeled compound is an essential internal standard for the precise quantitative analysis of Rimonabant in complex biological matrices using mass spectrometry. It is primarily used by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Bioanalytical Internal Standard: Serves as a critical internal standard for the accurate quantification of Rimonabant in plasma, serum, and tissue samples via LC-MS/MS.
• Pharmacokinetic (PK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism and Disposition (DMPK): Used in metabolite identification and profiling studies to understand the metabolic fate of Rimonabant.
• Method Development and Validation: Essential for developing, optimizing, and validating robust, GLP-compliant analytical methods.
• Reference Material: Acts as a high-purity certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity.
• Regulatory Submissions: Supports data packages for regulatory filings (e.g., FDA, EMA) by providing traceable and reliable quantitative data.

Basic Information

Item	Detail
Product Name	Rimonabant-D10
CAS No.	929221-88-5
Molecular Formula	C22H11D10Cl3N4O
Molecular Weight	463.82 g/mol
Synonyms	5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide-D10; SR141716-D10; Acomplia-D10; Deuterated Rimonabant; Rimonabant (D10); Rimonabant-d10; [D10]-Rimonabant; Cannabinoid CB1 Receptor Antagonist D10
EINECS	Contact for details

Quality Control

Every batch of Rimonabant-D10 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Our quality assurance includes comprehensive testing via NMR, HPLC, and mass spectrometry to confirm identity, chemical purity, and isotopic enrichment. A detailed Certificate of Analysis (COA), providing batch-specific data, is supplied with each product to support your quality and compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (LC-MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.