Description

Prasugrel Metabolite R-138727Mp is a key active metabolite of the antiplatelet drug Prasugrel, identified by CAS number 929211-64-3. This high-purity reference standard is critical for pharmaceutical research and development, enabling accurate pharmacokinetic and pharmacodynamic studies. It is primarily utilized by analytical laboratories and pharmaceutical manufacturers for method development, quality control, and regulatory compliance in the production of cardiovascular therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for the quantitative and qualitative analysis of Prasugrel and its metabolites in drug substances and products.
• Bioanalytical Research: Used in the development and validation of LC-MS/MS, HPLC, and other analytical methods for metabolite profiling in biological matrices.
• Pharmacology & Toxicology Studies: Essential for investigating the metabolic pathways, efficacy, and safety profile of Prasugrel in preclinical and clinical research.
• Drug Impurity Profiling: Employed to identify and quantify related substances and degradation products in Active Pharmaceutical Ingredient (API) batches.
• Regulatory Submissions: Provides certified material for inclusion in regulatory documentation (e.g., for FDA, EMA) to support drug approval and quality dossiers.
• Academic Research: Supports fundamental research in medicinal chemistry, cardiology, and platelet aggregation mechanisms at universities and research institutes.

Basic Information

Product Name	Prasugrel Metabolite R-138727Mp
CAS No.	929211-64-3
Molecular Formula	C16H16FNO3S
Molecular Weight	321.37 g/mol
Synonyms	R-138727; Prasugrel Active Metabolite; (5)-2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone; 2-[2-(Acetyloxy)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone; R138727; R-138727Mp; Prasugrel Metabolite R138727
EINECS	Contact for details

Quality Control

Our Prasugrel Metabolite R-138727Mp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity assay, residual solvent analysis, and structural confirmation (NMR, MS) to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with ICH guidelines and cGMP standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.