Description

Carvedilol-D5 is a deuterated analog of the non-selective β-blocker carvedilol, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard in quantitative bioanalytical methods, ensuring the accuracy and reliability of pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug development and regulatory compliance.

Application

• Primary use as an internal standard for the precise quantification of carvedilol in biological matrices (e.g., plasma, serum) using LC-MS/MS and GC-MS.
• Critical reference material for method development, validation, and quality control in bioanalytical laboratories.
• Facilitates metabolic studies and drug-drug interaction assessments by tracking the parent drug's fate.
• Supports pharmacokinetic (PK) and pharmacodynamic (PD) research during clinical trials for cardiovascular therapies.
• Used in the synthesis of other deuterated metabolites or related compounds for advanced research applications.
• Essential for ensuring data integrity in studies submitted for regulatory filings with agencies like the FDA and EMA.

Basic Information

Product Name	Carvedilol-D5
CAS No.	929106-58-1
Molecular Formula	C24H21D5N2O4
Molecular Weight	412.52 g/mol (approx.)
Synonyms	1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d5; (±)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d5; BM 14190-d5; Carvedilol (phenyl-d5); Carvedilol-d5 (deuterated); Carvedilol (deuterated standard); [2H5]-Carvedilol
EINECS	Contact for details

Quality Control

Our Carvedilol-D5 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and impurity profile. We adhere to relevant industry standards for reference materials, and our quality commitment ensures reliable and reproducible results in your sensitive analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.