Description

(2S)-[[[(Phenylmethoxy)Carbonyl]Amino]Methyl]-1-Pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex peptide and peptidomimetic structures, ensuring stereochemical integrity throughout multi-step processes. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and complex small molecule APIs.
• Peptidomimetic Research: Used to introduce proline-like, constrained structures into peptide backbones to enhance metabolic stability and bioavailability.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected amino acid derivative for the sequential assembly of custom peptides.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies by providing a versatile, stereodefined scaffold for library development.
• Bioconjugation: Can be utilized in the preparation of labeled peptides or peptide-drug conjugates for diagnostic or therapeutic purposes.
• Catalyst and Ligand Synthesis: Serves as a precursor for chiral ligands used in asymmetric catalysis.

Basic Information

Product Name	(2S)-[[[(Phenylmethoxy)Carbonyl]Amino]Methyl]-1-Pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	929048-08-8
Molecular Formula	C19H28N2O5
Molecular Weight	364.44 g/mol
Synonyms	(2S)-2-[[(Benzyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-(S)-2-(Cbz-aminomethyl)pyrrolidine; (S)-1-Boc-2-(Cbz-aminomethyl)pyrrolidine; tert-Butyl (2S)-2-[[(benzyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylate; (S)-1-(tert-Butoxycarbonyl)-2-((((benzyloxy)carbonyl)amino)methyl)pyrrolidine; Nα-Cbz-Nω-Boc-(S)-2,4-diaminobutyric acid lactam derivative; (2S)-1-(tert-Butoxycarbonyl)-2-((((benzyloxy)carbonyl)amino)methyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific results for assay, enantiomeric excess, and impurity profiles are available upon request. We adhere to strict quality management protocols suitable for cGMP and research-grade material supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.