Description

Human Noggin CAS NO 928858-36-0 is a highly purified recombinant protein that acts as a potent bone morphogenetic protein (BMP) antagonist. This critical signaling molecule is essential for regulating cell differentiation and tissue development, particularly in neural and skeletal systems. It is a fundamental research reagent for developmental biologists, stem cell researchers, and pharmaceutical scientists working on regenerative medicine, disease modeling, and high-throughput screening applications.

Application

• Stem Cell Research & Differentiation: Crucial for the maintenance and neural induction of pluripotent stem cells (ESCs and iPSCs).
• Developmental Biology Studies: Used to investigate embryonic patterning, neurogenesis, and organogenesis by inhibiting BMP signaling pathways.
• Regenerative Medicine: Serves as a key component in protocols for generating specific neural cell types for potential therapeutic applications.
• Biochemical Assays: Employed in ligand-receptor interaction studies, signal transduction research, and as a standard in quantitative assays.
• Drug Discovery & Screening: Used in target validation and high-content screening platforms to identify modulators of the BMP pathway.
• Cell Culture Supplement: Added to specialized media formulations to direct cell fate decisions in vitro.

Basic Information

Item	Details
Product Name	Human Noggin
CAS No.	928858-36-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Noggin, Recombinant Human Noggin, NOG, NOG_HUMAN, SYM1, SYNS1, BMP Antagonist Noggin, Neural Inducer Noggin
EINECS	Contact for details

Quality Control

Our Human Noggin is produced under stringent conditions and undergoes comprehensive analytical testing to ensure high purity, biological activity, and batch-to-batch consistency. Quality is verified through methods including SDS-PAGE, HPLC, and functional bioassays. A Certificate of Analysis (COA) detailing purity, endotoxin levels, and biological activity is provided with each shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White or off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Endotoxin Level	< 1.0 EU/µg
Biological Activity	Determined by BMP inhibition assay
Solubility	Soluble in sterile PBS or cell culture grade water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.