Description

Ethyl 3-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2,2-Difluoro-3-Hydroxypropionate is a high-value, multi-functional fluorinated building block and chiral synthon. This compound is critical for introducing difluorinated hydroxypropionate motifs into complex molecules, enabling the synthesis of novel compounds with enhanced biological activity and metabolic stability. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients, including potential antiviral, antibacterial, and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly those targeting infectious diseases and metabolic disorders.
• Agrochemical Synthesis: Used in R&D for creating advanced, fluorinated active ingredients in herbicides, fungicides, and insecticides to improve efficacy and environmental profile.
• Fluorine Chemistry Research: Serves as a versatile building block in academic and industrial laboratories for exploring new fluorination methodologies and creating fluorinated molecular libraries.
• Material Science Precursor: Potential use in the development of specialty polymers and advanced materials where the introduction of fluorine atoms can alter surface properties and stability.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and pilot-scale production of target molecules in a GMP or non-GMP environment.

Basic Information

Product Name	Ethyl 3-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2,2-Difluoro-3-Hydroxypropionate
CAS No.	928797-50-6
Molecular Formula	C₁₀H₁₆F₂O₅
Molecular Weight	254.23 g/mol
Synonyms	Ethyl 2,2-difluoro-3-hydroxy-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propanoate; 2,2-Difluoro-3-hydroxy-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionic Acid Ethyl Ester; (4R)-4-[(1R)-2-Ethoxy-1,1-difluoro-2-oxoethyl]-2,2-dimethyl-1,3-dioxolane; (4S)-4-[(1S)-2-Ethoxy-1,1-difluoro-2-oxoethyl]-2,2-dimethyl-1,3-dioxolane; Difluorohydroxypropionate Acetonide Ethyl Ester; Ethyl 3-Hydroxy-2,2-difluoro-3-(2,2-dimethyl-1,3-dioxolan-4-yl)propionate
EINECS	Contact for details

Quality Control

Our Ethyl 3-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-2,2-Difluoro-3-Hydroxypropionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC), identity confirmation (IR, NMR), and quantification of key impurities, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (specify isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.