Description

Ethyl 1-(Trifluoromethyl)Cyclopropanecarboxylate is a high-value fluorinated cyclopropane building block essential for advanced organic synthesis. This compound matters because its unique trifluoromethylcyclopropyl moiety imparts desirable metabolic stability and lipophilicity to target molecules, making it a critical intermediate in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating specialty polymers with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Research: A versatile substrate for studying cyclopropane ring-opening reactions and fluorination methodologies.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex fluorinated fine chemicals and flavors & fragrances.

Basic Information

Product Name	Ethyl 1-(Trifluoromethyl)Cyclopropanecarboxylate
CAS No.	139229-57-5
Molecular Formula	C7H9F3O2
Molecular Weight	182.14 g/mol
Synonyms	Ethyl 1-(Trifluoromethyl)cyclopropanecarboxylate; 1-(Trifluoromethyl)cyclopropanecarboxylic Acid Ethyl Ester; Ethyl 1-(Trifluoromethyl)cyclopropanecarboxylate; Ethyl 1-(Trifluoromethyl)cyclopropanecarboxylate; Trifluoromethylcyclopropanecarboxylic Acid Ethyl Ester; 1-Trifluoromethylcyclopropanecarboxylic Acid Ethyl Ester; Ethyl (1-Trifluoromethylcyclopropyl)carboxylate; 1-Carbethoxy-1-trifluoromethylcyclopropane
EINECS	Contact for details

Quality Control

Our Ethyl 1-(Trifluoromethyl)Cyclopropanecarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.390 - 1.400
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.