Description

2-Amino-3,3,3-trifluoro-2-methylpropanoic acid is a specialized non-proteinogenic amino acid derivative characterized by its trifluoromethyl and methyl substituents on the alpha carbon. This unique structure makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for introducing fluorine atoms to modulate the physicochemical and biological properties of target molecules. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides, where the trifluoromethyl group can enhance metabolic stability and lipophilicity.
• Peptide Mimetics & Modification: Incorporated into peptide chains to study structure-activity relationships (SAR) and improve peptide stability against enzymatic degradation.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers or specialty chemicals with unique surface properties.
• Biochemical Research: Used as a tool compound in enzymatic studies and metabolic pathway investigations due to its non-natural amino acid structure.

Basic Information

Product Name	2-Amino-3,3,3-trifluoro-2-methylpropanoic Acid
CAS No.	102210-02-6
Molecular Formula	C5H6F3NO2
Molecular Weight	157.10 g/mol
Synonyms	2-Amino-3,3,3-trifluoro-2-methylpropionic Acid; 3,3,3-Trifluoro-2-methylalanine; 2-Methyl-3,3,3-trifluoroalanine; (R/S)-2-Amino-3,3,3-trifluoro-2-methylpropanoic Acid; DL-3,3,3-Trifluoro-2-methylalanine; 2-Amino-2-methyl-3,3,3-trifluoropropanoic Acid; α-Amino-α-methyl-β,β,β-trifluoropropionic Acid; TFMA
EINECS	Contact for details

Quality Control

Our 2-Amino-3,3,3-trifluoro-2-methylpropanoic acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the exacting standards required for research and process development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.