Description

(S)-(-)-3,3,3-Trifluoro-2-Hydroxypropanoic Acid CAS NO 125995-00-8 is a high-value, chiral fluorinated building block essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals. Its unique trifluoromethyl and hydroxy acid functionalities make it a critical precursor for introducing stereochemistry and fluorine atoms into target molecules, enhancing their metabolic stability and bioavailability. This compound is primarily sought after by R&D and process development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of protease inhibitors, enzyme modulators, and other bioactive molecules where the trifluoromethyl group is crucial for activity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging fluorine's ability to improve lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Amino Acid Analog: Acts as a building block for incorporating non-natural, fluorinated amino acids into peptides and proteins for biochemical research.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty materials with unique surface properties.
• Diagnostic Reagent Precursor: Used in the development of contrast agents or labeled compounds for imaging technologies.

Basic Information

Product Name	(S)-(-)-3,3,3-Trifluoro-2-Hydroxypropanoic Acid
CAS No.	125995-00-8
Molecular Formula	C₃H₃F₃O₃
Molecular Weight	144.05 g/mol
Synonyms	(S)-3,3,3-Trifluoro-2-hydroxypropanoic acid; (S)-(-)-3,3,3-Trifluorolactic acid; (S)-Trifluorolactic acid; (2S)-3,3,3-Trifluoro-2-hydroxypropanoic acid; L-3,3,3-Trifluorolactic acid; (S)-TFL; (S)-α-Trifluoromethyl lactic acid; (S)-2-Hydroxy-3,3,3-trifluoropropanoic acid
EINECS	Contact for details

Quality Control

We supply (S)-(-)-3,3,3-Trifluoro-2-Hydroxypropanoic Acid in high-purity grades suitable for research and commercial synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles are available upon request. We adhere to cGMP and ISO 9001 principles for consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.