Description

1-Ethoxy-4-Ethynyl-2,3-Difluorobenzene is a high-value, multi-functional aromatic building block containing ethynyl and difluoro substituents. This compound is critical for advanced organic synthesis, particularly in the development of novel materials and active pharmaceutical ingredients (APIs). It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Research: Used in creating advanced herbicides and pesticides with enhanced activity and selectivity.
• Liquid Crystal & OLED Materials: Serves as a core building block for fluorine-containing electronic materials and display technologies.
• Polymer Chemistry: Monomer for specialty polymers, including polyacetylenes and fluorinated polymers with unique thermal and optical properties.
• Cross-Coupling Reactions: Valuable substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions due to the reactive ethynyl group.
• Chemical Synthesis Reagent: Used in academic and industrial research labs to introduce difluorobenzene and alkyne functionalities into target molecules.

Basic Information

Product Name	1-Ethoxy-4-Ethynyl-2,3-Difluorobenzene
CAS No.	928208-56-4
Molecular Formula	C10H8F2O
Molecular Weight	182.17 g/mol
Synonyms	4-Ethynyl-1-ethoxy-2,3-difluorobenzene; 2,3-Difluoro-4-ethynyl-1-ethoxybenzene; 1-Ethoxy-2,3-difluoro-4-ethynylbenzene; 4-Ethynyl-2,3-difluorophenyl ethyl ether; 2,3-Difluoro-4-ethynylanisole; Benzene, 1-ethoxy-4-ethynyl-2,3-difluoro-; (4-Ethoxy-2,3-difluorophenyl)acetylene
EINECS	Contact for details

Quality Control

Our 1-Ethoxy-4-Ethynyl-2,3-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Incompatible with strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.