Description

4-Bromo-3-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring both bromine and trifluoromethoxy substituents on a benzonitrile core. This unique structure makes it a critical building block for the synthesis of advanced materials and active pharmaceutical ingredients (APIs), offering significant advantages in tuning molecular properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with enhanced bioactivity and stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group can improve lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated aromatic components essential in electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Material Development: Employed in polymer chemistry and material science to introduce specific functional groups that alter thermal stability, solubility, or electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl systems.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on fluorine chemistry and the exploration of new chemical spaces.

Basic Information

Product Name	4-Bromo-3-(Trifluoromethoxy)Benzonitrile
CAS No.	928136-78-1
Molecular Formula	C8H3BrF3NO
Molecular Weight	266.02 g/mol
Synonyms	4-Bromo-3-(trifluoromethoxy)benzonitrile; 3-Trifluoromethoxy-4-bromobenzonitrile; Benzonitrile, 4-bromo-3-(trifluoromethoxy)-; 4-Bromo-α,α,α-trifluoro-m-anisonitrile; 4-Bromo-3-trifluoromethoxybenzonitrile; 928136-78-1
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.