Description

1-Piperidinecarboxylic Acid, 4-(5-Fluoro-1,2-Dihydrospiro[3H-Indole-3,4'-Piperidin]-1'-Yl)-, Ethyl Ester CAS NO 927402-26-4 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indole-piperidine scaffold. This compound is of significant commercial value for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) and oncology drugs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent, small-molecule drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Protease Inhibitor Development: The structural motif is valuable for creating inhibitors of specific enzymes involved in disease progression.
• Neurological Disorder Research: Serves as a core scaffold for compounds being investigated for conditions such as depression, anxiety, and neurodegenerative diseases.
• Oncology Drug Discovery: Utilized in the development of targeted cancer therapies due to its ability to modulate key cellular signaling proteins.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for scale-up and cGMP production of clinical trial materials.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 4-(5-Fluoro-1,2-Dihydrospiro[3H-Indole-3,4'-Piperidin]-1'-Yl)-, Ethyl Ester
CAS No.	927402-26-4
Molecular Formula	C20H26FN3O2
Molecular Weight	359.44 g/mol
Synonyms	Ethyl 4-(5-Fluoro-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-yl)piperidine-1-carboxylate; 4-(5-Fluoro-1,2-dihydrospiro[3H-indole-3,4'-piperidin]-1'-yl)-1-piperidinecarboxylic acid ethyl ester; 927402-26-4; UNII-9F3J6P6T6I; Spiro[indole-3,4'-piperidine] intermediate; 1'-[(1-Ethoxycarbonyl-4-piperidyl)]-5-fluorospiro[3H-indole-3,4'-piperidine]; 5-Fluoro-1'-[1-(ethoxycarbonyl)-4-piperidinyl]spiro[3H-indole-3,4'-piperidine]
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development work. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. We support development from research to commercial scale with appropriate documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.