Description

(S)-3,4,5-Meo-Meobiphep, Sl-A104-2, (S)-2,2'-Bis[Bis(3,4,5-Trimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl is a high-value, chiral bisphosphine ligand crucial for asymmetric catalysis. Its significance lies in its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer intermediates. This product is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing advanced active ingredients and specialty molecules.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, a key step in pharmaceutical synthesis.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in complex drug candidates, including those for cardiovascular, CNS, and oncology applications.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Enables the production of high-value chiral building blocks and flavors & fragrances.
• Catalyst Development & Screening: Serves as a benchmark ligand in academic and industrial research for developing new asymmetric catalytic processes.
• Cross-Coupling Reactions: Can be applied in asymmetric cross-coupling reactions to form carbon-carbon bonds with stereocontrol.

Basic Information

Item	Details
Product Name	(S)-3,4,5-Meo-Meobiphep, Sl-A104-2, (S)-2,2'-Bis[Bis(3,4,5-Trimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl
CAS No.	927396-01-8
Molecular Formula	C58H60O14P2
Molecular Weight	1043.01 g/mol
Synonyms	(S)-MeO-Biphep; (S)-2,2'-Bis(di-3,4,5-trimethoxyphenylphosphino)-6,6'-dimethoxy-1,1'-biphenyl; (S)-6,6'-Dimethoxy-2,2'-bis[bis(3,4,5-trimethoxyphenyl)phosphino]biphenyl; SL-A104-2; (S)-3,4,5-Trimethoxy-MeOBIPHEP; (S)-Bisphosphine ligand SL-A104-2; (S)-MeOBIPHEP derivative
EINECS	Contact for details

Quality Control

Every batch of our (S)-3,4,5-Meo-Meobiphep is manufactured and tested under strict quality management systems to ensure exceptional purity and chiral integrity, critical for reproducible catalytic performance. We employ advanced analytical techniques including HPLC, 31P NMR, and chiral analysis to verify identity, assay, and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product under an inert atmosphere (argon or nitrogen) at 2-8°C. The material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.