Description

(Le,4E)-Ethyl 8-Bromo-2-(tert-Butoxycarbonylamino)-3H-Benzo[B]Azepine-4-Carboxylate is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially benzazepine-based therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new bioactive molecules.
• Process Development & Scale-up: Serves as a reference standard and starting material for developing and validating robust, scalable manufacturing routes for APIs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry and novel synthetic methodologies.

Basic Information

Product Name	(Le,4E)-Ethyl 8-Bromo-2-(tert-Butoxycarbonylamino)-3H-Benzo[B]Azepine-4-Carboxylate
CAS No.	926927-57-3
Molecular Formula	C₁₈H₂₃BrN₂O₄
Molecular Weight	411.29 g/mol
Synonyms	Ethyl (4E)-8-bromo-2-[(tert-butoxycarbonyl)amino]-3H-1-benzazepine-4-carboxylate; 8-Bromo-2-[(tert-butoxycarbonyl)amino]-3H-1-benzazepine-4-carboxylic acid ethyl ester; (4E)-Ethyl 8-bromo-2-[(tert-butoxycarbonyl)amino]-3H-1-benzazepine-4-carboxylate; 926927-57-3; BOC-protected 8-bromo benzazepine carboxylate; tert-Butyl (4E)-8-bromo-4-(ethoxycarbonyl)-3H-1-benzazepin-2-ylcarbamate
EINECS	Contact for details

Quality Control

Our (Le,4E)-Ethyl 8-Bromo-2-(tert-Butoxycarbonylamino)-3H-Benzo[B]Azepine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.