Description

Fmoc-6-Chloro-D-Tryptophan CAS NO 925916-73-0 is a protected, non-natural amino acid derivative specifically engineered for advanced peptide synthesis. This compound is a critical chiral building block, offering precise stereochemical control for the development of novel peptide-based pharmaceuticals and research tools. It is primarily utilized by medicinal chemists and research scientists in the pharmaceutical, biotechnology, and academic sectors for creating complex peptide libraries and therapeutic candidates with enhanced stability and biological activity.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated, sequential assembly of peptides containing modified tryptophan residues.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of peptide drugs, hormone analogs, and enzyme inhibitors targeting various diseases.
• Peptidomimetic Design: Incorporation into peptide backbones to enhance metabolic stability, receptor selectivity, and overall drug-like properties.
• Chemical Biology Probes: Synthesis of labeled or tagged peptides for studying protein-protein interactions, cellular localization, and biochemical pathways.
• Antibiotic and Antimicrobial Peptide Synthesis: Building block for developing novel antimicrobial agents with modified side chains for improved efficacy.
• Academic & Contract Research: Essential reagent for university laboratories and CROs (Contract Research Organizations) conducting cutting-edge peptide science.

Basic Information

Product Name	Fmoc-6-Chloro-D-Tryptophan
CAS No.	925916-73-0
Molecular Formula	C₂₆H₂₁ClN₂O₄
Molecular Weight	460.91 g/mol
Synonyms	Fmoc-6-Cl-D-Trp-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-6-chloro-D-tryptophan; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(6-chloro-1H-indol-3-yl)propanoic acid; Fmoc-6-chloro-D-tryptophan; 6-Chloro-D-tryptophan Fmoc derivative; N-Fmoc-6-chloro-D-tryptophan; Fmoc-D-Trp(6-Cl)-OH; Fmoc-6-Cl-Trp-OH (D-isomer)
EINECS	Contact for details

Quality Control

Our Fmoc-6-Chloro-D-Tryptophan is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.