Description

(2-[(tert-Butoxycarbonyl)Amino]-5-Fluorophenyl)Boronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. Its core value lies in its dual functionality, featuring a protected amine group and a boronic acid moiety, making it essential for modern cross-coupling reactions like the Suzuki-Miyaura reaction. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Essential reagent for forming carbon-carbon bonds between aromatic rings, enabling the construction of complex biaryl structures common in modern drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific fluorinated aromatic scaffolds.
• Material Science: Serves as a precursor for creating functionalized polymers and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-fidelity boronic acid derivatives.

Basic Information

Product Name	(2-[(tert-Butoxycarbonyl)Amino]-5-Fluorophenyl)Boronic Acid
CAS No.	925207-17-6
Molecular Formula	C11H15BFNO4
Molecular Weight	255.06 g/mol
Synonyms	Boc-2-Amino-5-fluorophenylboronic Acid; N-Boc-2-Amino-5-fluorobenzeneboronic Acid; 2-[(tert-Butoxycarbonyl)amino]-5-fluorobenzeneboronic Acid; 5-Fluoro-2-[(2-methylpropan-2-yl)oxycarbonylamino]phenylboronic Acid; 2-(Boc-amino)-5-fluorophenylboronic Acid; 2-Amino-5-fluorophenylboronic acid N-Boc protected; 925207-17-6; tert-Butyl (5-fluoro-2-boronophenyl)carbamate
EINECS	Contact for details

Quality Control

Our (2-[(tert-Butoxycarbonyl)Amino]-5-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.