Description

5-Chloro-2-Fluoroisonicotinonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Development: Used in the creation of new herbicides and fungicides, leveraging the biological activity of the fluoro- and chloro-substituted pyridine core.
• Material Science Research: Serves as a building block for functionalized ligands in catalysis or for creating specialty polymers with tailored electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Chloro-2-Fluoroisonicotinonitrile
CAS No.	924651-91-2
Molecular Formula	C6HClFN2
Molecular Weight	156.53 g/mol
Synonyms	5-Chloro-2-fluoropyridine-4-carbonitrile; 2-Fluoro-5-chloro-4-cyanopyridine; 4-Cyano-5-chloro-2-fluoropyridine; 5-Chloro-2-fluoro-4-pyridinecarbonitrile; 924651-91-2; 5-Chloro-2-fluoropyridine-4-carbonitrile; 2-Fluoro-5-chloroisonicotinonitrile
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-Fluoroisonicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.