Description

[1-(2R,5R)-2,5-Diethylphospholanyl]-[2-(2R,5R)-2,5-Diethylphospholanyl-1-Oxide]Benzene, Min. 97% is a high-purity, chiral phosphine-oxazoline hybrid ligand, a critical component in asymmetric catalysis. This compound is valued for its ability to induce high enantioselectivity in transition metal-catalyzed reactions, enabling the production of single-enantiomer intermediates essential for advanced pharmaceuticals and fine chemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel synthetic pathways.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for synthesizing chiral active pharmaceutical ingredients (APIs).
• Asymmetric C-C Bond Formation: Employed in reactions such as Heck couplings, Suzuki-Miyaura cross-couplings, and allylic alkylations to construct complex molecular architectures with high stereocontrol.
• Pharmaceutical Intermediate Synthesis: Facilitates the production of single-enantiomer drug candidates for therapeutic areas including oncology, CNS disorders, and infectious diseases.
• Agrochemical Active Ingredient Development: Used in the synthesis of chiral herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Academic and Industrial R&D: Serves as a versatile tool for methodology development and exploring new catalytic transformations in academic laboratories and corporate research centers.
• Fine Chemical and Flavor/Fragrance Synthesis: Applied in the preparation of high-value chiral compounds where optical purity is paramount.

Basic Information

Product Name	[1-(2R,5R)-2,5-Diethylphospholanyl]-[2-(2R,5R)-2,5-Diethylphospholanyl-1-Oxide]Benzene, Min. 97%
CAS No.	924294-55-3
Molecular Formula	C24H40NO2P2
Molecular Weight	460.52 g/mol
Synonyms	(R,R)-[1-(2,5-Diethylphospholanyl)-2-(2,5-diethylphospholanyl-1-oxide)]benzene; (R,R)-DIPAMP Oxide Derivative; Chiral Phosphine-Oxazoline Ligand; (R,R)-Benzene-1,2-diylbis((2R,5R)-2,5-diethylphospholane 1-oxide); Asymmetric Hydrogenation Ligand; Josiphos-type Oxazoline Ligand; P,N-Hybrid Ligand; 924294-55-3
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management protocols to ensure consistent high purity and enantiomeric integrity, which are non-negotiable for catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess (ee), and impurity profiles determined by HPLC, NMR, and chiral analysis. Our commitment to quality supports compliance with cGMP and ISO 9001 standards for advanced chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	Min. 97.0%
Enantiomeric Purity (Chiral HPLC)	Min. 99.0% ee
Loss on Drying	Max. 0.5%
Residue on Ignition	Max. 0.1%
Heavy Metals (as Pb)	Max. 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.