Description

Glycine, n-(3,5-Difluorobenzoyl)- is a high-purity, fluorinated benzoyl glycine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a versatile, difluorinated aromatic building block that enables the introduction of specific fluorine atoms and amide linkages into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals where precise fluorination is required for modulating biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases where fluorination is a common strategy.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging the difluorobenzoyl moiety to enhance compound lipophilicity, bioavailability, and target binding.
• Peptidomimetics & Bioactive Molecule Synthesis: Serves as a constrained amino acid derivative for constructing peptide analogs and other bioactive molecules, influencing their conformation and interaction with biological targets.
• Material Science Precursor: Potential use as a monomer or functionalization agent in the synthesis of specialized polymers and advanced materials with unique surface properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for studying biochemical pathways and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to custom synthesis laboratories and CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Item	Detail
Product Name	Glycine, n-(3,5-Difluorobenzoyl)-
CAS No.	923691-92-3
Molecular Formula	C9H7F2NO3
Molecular Weight	215.15 g/mol
Synonyms	N-(3,5-Difluorobenzoyl)glycine; 2-[(3,5-Difluorobenzoyl)amino]acetic acid; 3,5-Difluorohippuric Acid; Glycine, N-(3,5-difluorobenzoyl)-; Hippuric acid, 3,5-difluoro-; UNII-9F3Q8P3Q5F; 923691-92-3; Acetic acid, 2-[(3,5-difluorobenzoyl)amino]-
EINECS	Contact for details

Quality Control

Our Glycine, n-(3,5-Difluorobenzoyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.