Description

(R)-A-(Fmoc-Amino)Cyclobutaneacetic Acid CAS NO 923012-41-3 is a high-purity, non-natural amino acid derivative featuring a cyclobutane ring and an Fmoc-protected amine group. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of constrained, conformationally rigid structures. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides, protease inhibitors, and other bioactive molecules where backbone rigidity and stereochemical control are essential.

Application

• Peptide Drug Discovery: As a key chiral intermediate in Solid-Phase Peptide Synthesis (SPPS) for creating peptide libraries and lead candidates with enhanced metabolic stability.
• Peptidomimetic Design: Incorporation into scaffolds to mimic peptide secondary structures, useful in developing enzyme inhibitors and receptor antagonists.
• Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs) for targeted therapies, including oncology and metabolic disease treatments.
• Bioconjugation & Probe Development: Used in the synthesis of labeled peptides for diagnostic imaging, biomarker studies, and drug delivery systems.
• Academic & Contract Research: Serves as a specialized reagent in university and CRO laboratories for studying structure-activity relationships (SAR).
• Process Chemistry: Scaling up for the GMP-compliant production of peptide-based drugs under stringent quality control.

Basic Information

Product Name	(R)-A-(Fmoc-Amino)Cyclobutaneacetic Acid
CAS No.	923012-41-3
Molecular Formula	C21H21NO4
Molecular Weight	351.40 g/mol
Synonyms	(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclobutaneacetic acid; (R)-2-(Fmoc-amino)cyclobutaneacetic acid; Fmoc-(R)-Ac4-OH; Fmoc-(R)-2-aminocyclobutaneacetic acid; (R)-1-(Fmoc-amino)cyclobutane-1-acetic acid; (R)-α-(Fmoc-amino)cyclobutaneacetic acid; (R)-N-Fmoc-2-aminocyclobutaneacetic acid; (R)-Fmoc-Ac4-OH
EINECS	Contact for details

Quality Control

Our (R)-A-(Fmoc-Amino)Cyclobutaneacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical assay, and impurity profiles. We adhere to industry best practices and can support development projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.