Description

Omeprazole-4-Methoxy-D3 is a deuterium-labeled analog of the proton pump inhibitor omeprazole, specifically modified at the 4-methoxy position. This stable isotope-labeled compound is an essential internal standard for the precise quantification of omeprazole and its metabolites in complex biological matrices using advanced analytical techniques. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Bioanalytical Internal Standard: Serves as a critical reference standard in LC-MS/MS and GC-MS assays for the accurate measurement of omeprazole in plasma, serum, and other biological fluids.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based studies to track drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Pharmaceutical Quality Control: Employed in the development and validation of analytical methods for the purity and stability testing of omeprazole-based drug substances and products.
• Clinical Research: Facilitates therapeutic drug monitoring and comparative bioavailability/bioequivalence studies in clinical trial settings.
• Forensic and Toxicological Analysis: Aids in the detection and quantification of omeprazole in forensic investigations and toxicology reports.
• Stable Isotope Labeling Studies: Used as a tracer in mechanistic studies to elucidate metabolic pathways and degradation products.

Basic Information

Item	Details
Product Name	Omeprazole-4-Methoxy-D3
CAS No.	922731-10-0
Molecular Formula	C₁₇H₁₆D₃N₃O₃S
Molecular Weight	Approx. 346.41 g/mol
Synonyms	5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl-d3)methyl]sulfinyl]-1H-benzimidazole; Omeprazole D3 (4-Methoxy); 4-Methoxy-d3-Omeprazole; Deuterated Omeprazole (4-OCH3); 5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl-d3)methyl]sulfinyl}-1H-benzimidazole; (RS)-Omeprazole-4-methoxy-d3; Stable Isotope Labeled Omeprazole
EINECS	Contact for details

Quality Control

Every batch of Omeprazole-4-Methoxy-D3 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive mass spectrometry applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting critical parameters including chemical purity, isotopic purity (enrichment), and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.