Description

Esomeprazole Sodium D6 CAS NO 922731-04-2 is a high-purity, deuterium-labeled isotopologue of the active pharmaceutical ingredient esomeprazole sodium. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, providing critical accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D and quality control laboratories engaged in the development and analysis of proton pump inhibitor drugs.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of esomeprazole in biological matrices (plasma, serum, urine).
• Metabolic and Pharmacokinetic (PK/PD) Studies to understand the absorption, distribution, metabolism, and excretion of esomeprazole.
• Supporting Bioequivalence and Clinical Trial research for generic and novel drug formulations.
• Use in Stable Isotope Dilution Assays to ensure high precision and accuracy in analytical results.
• Reference material for Pharmaceutical Quality Control laboratories to validate analytical methods.
• Research applications in Drug Metabolism and enzymology studies related to the CYP450 system.

Basic Information

Product Name	Esomeprazole Sodium D6
CAS No.	922731-04-2
Molecular Formula	C17H14D6N3NaO3S
Molecular Weight	367.42 g/mol (approx.)
Synonyms	(S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl-D6)methyl]sulfinyl]-1H-benzimidazole Sodium Salt; Esomeprazole-D6 Sodium Salt; Dexlansoprazole Impurity D6 (related compound); Perdeuterated Esomeprazole Sodium; Nexium-D6 Internal Standard; 6-Deuteromethoxy-2-[(4-deuteromethoxy-3,5-bis(deuteromethyl)-2-pyridinyl-D3)methylsulfinyl]-1H-benzimidazole Sodium Salt
EINECS	Contact for details

Quality Control

Our Esomeprazole Sodium D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We adhere to relevant GMP guidelines for the production of reference standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.