Description

Omeprazole-D3 is a deuterium-labeled analog of the widely used proton pump inhibitor, omeprazole. This stable isotope-labeled compound is an essential reference standard and internal standard for the accurate quantification and pharmacokinetic study of omeprazole in biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and bioanalytical method development.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise bioanalysis of omeprazole.
• Critical reference material for method development, validation, and quality control in pharmacokinetic and pharmacodynamic studies.
• Used in drug metabolism research to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of omeprazole.
• Essential for conducting clinical trials and therapeutic drug monitoring (TDM) programs requiring high analytical accuracy.
• Application in forensic and toxicological analysis for the definitive identification and quantification of omeprazole.
• Serves as a key starting material or intermediate in the synthesis of other deuterated compounds for research purposes.

Basic Information

Product Name	Omeprazole-D3
CAS No.	922731-01-9
Molecular Formula	C17H16D3N3O3S
Molecular Weight	348.42 g/mol
Synonyms	5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)(D3)methyl]sulfinyl]-1H-benzimidazole; (D3)Omeprazole; Omeprazole (methyl-D3); Omeprazole-d3; 1H-Benzimidazole, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl-d3]sulfinyl]-; Deuterated Omeprazole; 5-Methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)(D3)methyl]sulfinyl}-1H-1,3-benzodiazole
EINECS	Contact for details

Quality Control

Our Omeprazole-D3 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, which are critical for its use as an analytical standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment, and chromatographic profile. We support research and compliance needs by providing traceable documentation for use in GLP/GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.