Description

Omeprazole-D3 Sulfide is a deuterated isotopologue of a key synthetic intermediate for the proton pump inhibitor omeprazole. This compound is specifically valued for its role as an internal standard in mass spectrometry-based bioanalytical methods, ensuring precise and accurate quantification in complex matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers engaged in drug metabolism and pharmacokinetics (DMPK) studies, stability testing, and quality control of omeprazole and related formulations.

Application

• Primary use as a stable isotope-labeled internal standard for the quantification of omeprazole and its metabolites in biological samples via LC-MS/MS.
• Critical component in pharmacokinetic (PK) and bioequivalence studies for omeprazole-based drugs.
• Facilitates drug metabolism research, aiding in the identification and measurement of metabolic pathways.
• Enhances accuracy in clinical trial sample analysis, ensuring reliable data for regulatory submissions.
• Used in pharmaceutical quality control laboratories for method development and validation.
• Supports forensic and toxicological analysis where precise measurement of omeprazole is required.

Basic Information

Product Name	Omeprazole-D3 Sulfide
CAS No.	922731-00-8
Molecular Formula	C17H16D3N3O2S
Molecular Weight	Approx. 328.41 g/mol
Synonyms	5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl-D3)methyl]sulfinyl]-1H-benzimidazole; 5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl-D3)methyl]sulfinyl}-1H-benzimidazole; Omeprazole D3 Sulfide; Omeprazole-d3 Sulfide Intermediate; Deuterated Omeprazole Sulfide; (RS)-Omeprazole-d3 Sulfide
EINECS	Contact for details

Quality Control

Our Omeprazole-D3 Sulfide is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, essential for its role as an analytical standard. Each batch undergoes comprehensive testing, including HPLC for chemical purity, NMR and MS for isotopic enrichment verification, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided, confirming compliance with specified standards. We support cGMP and ISO 9001 aligned practices for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.