Description

Omeprazole-D3 Sulfide is a deuterium-labeled analog of a key omeprazole intermediate. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of analytical methods in pharmaceutical research and development. It is primarily used by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for use as an internal standard in mass spectrometry. This enables precise quantification and metabolic studies of omeprazole and related proton pump inhibitors.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of omeprazole and its metabolites in biological matrices like plasma and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of omeprazole.
• Bioanalytical Method Development and Validation: Essential for developing and validating robust, regulatory-compliant analytical methods for bioequivalence and clinical trials.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during drug substance manufacturing.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies in pharmacology and medicinal chemistry due to its deuterium-labeled structure.

Basic Information

Product Name	Omeprazole-D3 Sulfide
CAS No.	922730-98-1
Molecular Formula	C17H16D3N3O2S
Molecular Weight	Approx. 330.41 g/mol
Synonyms	5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl-d3)methyl]thio]-1H-benzimidazole; Deuterated Omeprazole Sulfide; Omeprazole Sulfide-d3; 5-Methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridinyl-d3)methyl]sulfanyl}-1H-1,3-benzodiazole; (RS)-Omeprazole Sulfide-d3; Omeprazole Related Compound D-d3 (Sulfide)
EINECS	Contact for details

Quality Control

Our Omeprazole-D3 Sulfide is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, which is critical for its function as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment, and impurity profile. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.