Description

3-Hydroxy Dexamethasone is a key synthetic corticosteroid derivative, specifically a hydroxylated analog of dexamethasone. This compound is of significant interest in pharmaceutical research and development due to its potential for enhanced metabolic stability and altered receptor binding affinity compared to its parent molecule. It serves as a critical intermediate and reference standard for the synthesis and analytical characterization of novel anti-inflammatory and immunosuppressive agents. This high-purity material is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel corticosteroid-based therapeutics.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) of related steroid compounds via HPLC, LC-MS, or NMR.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor (GR) interactions, structure-activity relationships (SAR), and metabolic pathways.
• Process Development: Utilized in scaling up and optimizing manufacturing routes for advanced steroid APIs (Active Pharmaceutical Ingredients).
• Metabolite Studies: Acts as a standard or synthetic target for identifying and characterizing dexamethasone metabolites in pharmacokinetic research.

Basic Information

Product Name	3-Hydroxy Dexamethasone
CAS No.	922713-68-6
Molecular Formula	C22H29FO6
Molecular Weight	408.46 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 3-Hydroxydexamethasone; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione; Dexamethasone 3-ol; Dexamethasone hydroxy analog
EINECS	Contact for details

Quality Control

Our 3-Hydroxy Dexamethasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Specifications are aligned with research-grade and potential pharmaceutical intermediate requirements. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for key parameters such as assay, related substances, and identification.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.