Description

1-Fluoropropan-2-Amine Hydrochloride is a high-purity fluorinated amine salt, serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing fluorine-containing motifs, which are essential for modulating the physicochemical and metabolic properties of target molecules. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and material science industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the preparation of novel herbicides, pesticides, and fungicides where the fluorine atom enhances bioavailability and environmental stability.
• Chemical Biology & Proteomics: Serves as a versatile reagent for labeling and modifying biomolecules in probe development and activity-based protein profiling (ABPP).
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and electronic materials requiring specific dielectric properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed amination (Buchwald-Hartwig) and other metal-mediated coupling reactions to construct complex amines.
• Asymmetric Synthesis: Useful as a chiral amine derivative or resolving agent in the preparation of enantiomerically pure compounds.

Basic Information

Product Name	1-Fluoropropan-2-Amine Hydrochloride
CAS No.	921602-78-0
Molecular Formula	C₃H₈FClN
Molecular Weight	113.55 g/mol
Synonyms	1-Fluoro-2-aminopropane Hydrochloride; 2-Amino-1-fluoropropane Hydrochloride; 1-Fluoro-2-propanamine Hydrochloride; 1-Fluoroisopropylamine Hydrochloride; (±)-1-Fluoropropan-2-amine Hydrochloride; DL-1-Fluoropropan-2-amine Hydrochloride; 2-Fluoro-1-methylethylamine Hydrochloride; 1-Fluoro-2-propylamine Hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Fluoropropan-2-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.