Description

(4-Amino-2-Fluorophenyl)Boronic Acid is a high-purity, functionalized boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, featuring both a reactive boronic acid group and a protected amino group, making it indispensable for Suzuki-Miyaura cross-coupling reactions. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorine atom and aromatic amine enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and OFETs, and in the construction of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs).
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes, sensors, and affinity ligands due to its specific binding interactions.
• Cross-Coupling Reactions: Serves as a superior aryl donor in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures with high efficiency.

Basic Information

Product Name	(4-Amino-2-Fluorophenyl)Boronic Acid
CAS No.	921211-27-0
Molecular Formula	C6H7BFNO2
Molecular Weight	154.94 g/mol
Synonyms	2-Fluoro-4-aminophenylboronic Acid; 4-Amino-2-fluorobenzeneboronic Acid; (4-Amino-2-fluorophenyl)boronic Acid; B-(4-Amino-2-fluorophenyl)boronic Acid; 2-Fluoro-4-aminobenzeneboronic Acid; 4-Amino-2-Fluorophenylboronic Acid Pinacol Ester (common derivative); 2-Fluoro-4-aminophenyl-Boronic Acid
EINECS	Contact for details

Quality Control

Our (4-Amino-2-Fluorophenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for sensitive coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.